Pesquisa sobre:
STAT TRANSCRIPTION FACTORS
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DeCS
Descritor
Inglês
:
STAT Transcription Factors
Descritor
Espanhol
:
Factores de Transcripción STAT
Descritor
Português
:
Fatores de Transcrição STAT
Categoria:
D12.644.360.024.342
D12.776.157.057.186
D12.776.476.024.421
D12.776.930.840
Definição
Inglês
:
A
family
of
transcription factors
containing SH2 DOMAINS that are involved in CYTOKINE-mediated
SIGNAL TRANSDUCTION
.
STAT transcription factors
are recruited to the cytoplasmic region of CELL SURFACE RECEPTORS and are activated via
PHOSPHORYLATION
. Once activated they dimerize and translocate into the
CELL NUCLEUS
where they influence
GENE expression
. They play a role in regulating
CELL GROWTH PROCESSES
and
CELL DIFFERENTIATION
.
STAT transcription factors
are inhibited by
SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS
and
PROTEIN INHIBITORS OF ACTIVATED STAT.
Nota de Indexação
Inglês
:
general; prefer specifics
Nota Histórica
Inglês
:
2006
Qualificadores Permitidos
Inglês
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número do Registro:
50795
Identificador Único:
D050791
Ocorrência na BVS
:
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